As I said previously, none of this is new. To me, all the fuss about this study, which has led Cipriani et al to reflect on it, seems to have been created because this is 6 years work which only reaches weak conclusions. Going slightly off message, they go on to argue for open access to data from clinical trials at the anonymised individual patient level. Having always been open in this blog, I couldn’t agree more, although I suspect that all this will do is show up even more biases in the data.
Anyway, Cipriani et al seem to be agreeing the debate about antidepressant efficacy has not been ended by their study. As I have said several times previously, I would also encourage them to research the placebo amplification hypothesis, however difficult this may be.