An article in JAMA Psychiatry reports a secondary analysis of a randomised controlled trial of antipsychotic medication to show that antipsychotic medication is associated with changes in brain structure. Exposure to olanzapine compared with placebo was associated with significant decreases in cortical thickness in the left hemisphere in those who sustained remission. This kind of finding is is not new (see previous post). Postmortem studies in animals have been linked to imaging findings (Vernon et al, 2013, Konopaske et al, 2007).
The clinical significance of these findings is unclear. How adverse these apparent brains changes are requires further elucidation.
(With thanks to Mad in America research news item by Peter Simons)