The article therefore confirms that the serotonin theory has been endorsed by the professional and academic community. Psychiatrists need to take responsibility for promoting the theory (see previous post). Psychiatry has always held out the hope that it will find the answer to mental illness but it needs to accept its limitations (see eg. another previous post). Although it may seem to make sense to us that we should be able to find a biological cause for mental illness, such as chemical imbalance in the brain, that doesn't justify wish-fulfilling unproven phantasies and even their publication in the academic literature (see yet another previous post). In fact, it's people that become depressed, not their brains, whether chemically imbalanced or not (see previous post).
Monday, April 25, 2022
Blaming chemical imbalance in the brain for depression does not make sense
2022) found that 23 out of 30 papers between 1990 and 2010 reviewing the aetiology of depression explicitly discussed the serotonin hypothesis and that 11 of them unequivocally supported the hypothesis. Another 9 papers, mainly stressed that depression is caused by an interaction of a multiplicity of factors and acknowledged the inconsistencies of the research on serotonin function, but nonetheless suggested that serotonin abnormalities mediate depressive symptom production or effects of antidepressants. Only one paper discounted the hypothesis. Of another 30 papers specifically examining the link between serotonin and depression, 16 gave unequivocal support for serotonin having a direct role in the aetiology of depression and only one discounted or challenged the hypothesis. Six well-known psychiatry and psychopharmacology textbooks published in the same period all acknowledged that the serotonin hypothesis is ultimately a hypothesis and not necessarily proven, but nevertheless devoted considerable space to coverage of the theory, providing some degree of support or endorsement for the hypothesis.