Sunday, February 20, 2011
Rank order of antipsychotics for producing weight gain
review in the Archives of General Psychiatry looks at the evidence for weight gain and changes in other cardiovascular risk factors caused by antipsychotic treatment. It has produced a rank order of the different drugs with olanzapine noted to cause more weight gain than all other second-generation antipsychotics except clozapine. Clozapine causes more weight gain than risperidone, risperidone more than amisulpride, and sertindole more than risperidone. The average weight gain after 6 to 8 weeks taking olanzapine was found to be 5 to 6 kg, which was significantly higher than the average weight gained while taking risperidone (4 kg) or haloperidol (3 kg).