Is the mystical-type experience induced by psychedelics of benefit in depression? Any effects of psychedelics in depression may merely be due to the placebo effect. Participants in trials can usually tell if they have been given psychedelic vs placebo, so trials are not double-blind, which makes them biased.
If one of the most biomedical of journals can see the disadvantages and risks of approving psychedelics for depression, then surely this needs to be taken seriously. Trouble is that I doubt it will, if only to meet the wish-fulling phantasies of psychiatry and people in general about overcoming depression with medication.