I very much welcome this work. However, I do remain perhaps more sceptical than Jo about the evidence. For example, I am not convinced about what she says about the emotional numbing (see eg. previous post) and physical dependency effects of SSRIs (see eg. another previous post).
I also think she is too generous to the idea that even though the serotonin theory of depression is wrong, that there may still be a biological explanation of depression. Don’t get me wrong! Of course depression is due to the brain. That’s mere tautology. But depression is a personal experience. It doesn’t make sense to look for it in the brain (see eg. previous post).